| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10815675 | Cellular Signalling | 2012 | 12 Pages |
Abstract
⺠Specific coupling of HRH1 to Gq is used to analyze the role of Gαq in LARG activation. ⺠HRH1-mediated LARG activation requires the LARG PDZ domain. ⺠Gαq-mediated activation of LARG is independent of PLCβ activation. ⺠Gαq-mediated activation of LARG requires no more than the LARG DH-PH tandem. ⺠Mechanisms of Gαq-mediated activation of LARG, p63RhoGEF, and PLCβ3 are distinct.
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Authors
Mariana Pfreimer, Petra Vatter, Torben Langer, Thomas Wieland, Peter Gierschik, Barbara Moepps,