Phosphorylation of the M3/6 dual-specificity phosphatase enhances the activation of JNK by arsenite

Article ID	Journal	Published Year	Pages	File Type
10815676	Cellular Signalling	2012	13 Pages	PDF

Abstract

âº The JNK-specific M3/6 phosphatase is phosphorylated in response to arsenite. âº Phosphorylation sites on M3/6 were mapped and mutated to analyze their role. âº No effect seen on M3/6 activity, specificity, JNK & JIP interactions, or stability. âº The M3/6 phosphorylation mutants delayed JNK activation in response to arsenite. âº JNK-induced phosphorylation of M3/6 temporally modulates the response to stress.

Keywords

Jnk MKP SAPK JIP JNK-interacting protein c-Jun N-terminal kinase DUSP MAP kinase phosphatase MAPK arsenite dual-specificity phosphatase Protein phosphorylation mitogen-activated protein kinase Stress-activated protein kinase