Human telomerase represses ROS-dependent cellular responses to Tumor Necrosis Factor-α without affecting NF-κB activation

► We overexpress hTERT human telomerase and monitor fibroblast responses to TNF-α. ► We find that hTERT reduces ROS levels and cell death in TNF-α-treated cells. ► hTERT overexpression induces constitutive nuclear accumulation of inactive NF-κ-Bp65. ► hTERT has no global impact on NF-κ-B signaling but reduces ROS-induced transcription. ► We conclude that hTERT is able to modulate ROS-dependent responses to TNF-α.