Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10815684 | Cellular Signalling | 2012 | 8 Pages |
Abstract
⺠IL-4-induced Stat6 activities represent naturally occurring Stat6 phenotypes with the active Stat6high phenotype (HT-29 cell line) favoring a Th2 cytokine environment and the defective Stat6null phenotype (Caco-2 cell line) favoring a Th1 cytokine environment. ⺠Cancer cells carrying active Stat6high phenotype harbor a microenvironment with preferably expressed genes relating to growth promotion, apoptotic resistance and pro-invasiveness/metastasis, while cancer cells carrying defective Stat6null phenotype, reciprocally, embraces a microenvironment with preferably expressed genes emphasizing growth inhibition, pro-apoptosis and anti-metastasis. ⺠The xenograft tumors carrying Stat6high phenotype have a growth advantage in vivo over the xenograft tumors carrying Stat6null phenotype.
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Authors
Ben Hui Li, Shuang Bing Xu, Feng Li, Xiao Guang Zou, Abudukeyoumu Saimaiti, Dilixia Simayi, Ying Hong Wang, Yan Zhang, Jia Yuan, Wen Jie Zhang,