| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10815688 | Cellular Signalling | 2012 | 8 Pages |
Abstract
⺠We discovered novel roles of JAK3 in myogenic differentiation. ⺠JAK3 inhibition enhances formation of multinucleated myotubes. ⺠Inhibition of JAK3 increases expressions of muscle specific genes and IGF-II. ⺠JAK3 inhibition regulates activities of STAT1 and STAT3 in myogenic differentiation. ⺠ERK and PI3K/AKT pathways are also regulated by JAK3 inhibition.
Keywords
PI3KDifferentiation mediaMCKMyogeninJAK3MLCIGF-IIMGNbHLHSTAT3ERKmTORJnkMEF2Janus kinasec-Jun N-terminal kinaseMRFsStat1STATbasic helix–loop–helixInsulin-like growth factor-IIMyoblast differentiationGrowth mediamyosin light chainMyosin heavy chainmuscle creatine kinaseMyogenic regulatory factorsPhosphatidylinositol 3-kinaseSignal transducer and activator of transcriptionMHCmammalian target of rapamycinJAKextracellular signal-regulated kinase
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Authors
You-Na Jang, Il Jae Lee, Myong Chul Park, Eun Joo Baik,