Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10815750 | Cellular Signalling | 2010 | 11 Pages |
Abstract
Recently we became aware of a possible mechanism of early phase TRAIL resistance development through internalization and degradation of TRAIL receptors (DR4 and DR5). Our current studies demonstrate that TRAIL receptors rapidly diminish at the membrane as well as the cytoplasm within 4Â h after TRAIL exposure, but recover completely after one or two days. Our studies also reveal that Cbl, a ubiquitously expressed cytoplasmic adaptor protein, is responsible for the rapid degradation of TRAIL receptors; Cbl binds to them and induces monoubiquitination of these receptors concurrent with their degeneration soon after TRAIL exposure, creating the early phase of acquired TRAIL resistance.
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Authors
Jae J. Song, Miroslaw Jerzy Szczepanski, So Young Kim, Joo-Hang Kim, Jee Young An, Yong Tae Kwon, Marco A. Jr, David L. Bartlett, Yong J. Lee,