| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10815818 | Cellular Signalling | 2011 | 11 Pages |
Abstract
LPS increased NO
- - production, iNOS protein levels and NF-κB nuclear levels; concomitantly with NO
- - production, LPS increased the neuronal migration as compared to non stimulated cultures. The necessary roles of the NO
- - and iNOS were demonstrated by chelating of NO
- - with hemoglobin and the inhibition of iNOS by 1400 W. Each of these treatments reduced neuronal migration induced by LPS. The role of NF-κB was showed by using the inhibitor JSH-23, which decreased NO
- - production and neuronal migration in LPS activated cultures. These results suggest that neuronal migration during development is susceptible to be modified by pro-inflammatory stimulus such as LPS through intracellular pathways associated with their receptors.
- - production, iNOS protein levels and NF-κB nuclear levels; concomitantly with NO
- - production, LPS increased the neuronal migration as compared to non stimulated cultures. The necessary roles of the NO
- - and iNOS were demonstrated by chelating of NO
- - with hemoglobin and the inhibition of iNOS by 1400 W. Each of these treatments reduced neuronal migration induced by LPS. The role of NF-κB was showed by using the inhibitor JSH-23, which decreased NO
- - production and neuronal migration in LPS activated cultures. These results suggest that neuronal migration during development is susceptible to be modified by pro-inflammatory stimulus such as LPS through intracellular pathways associated with their receptors.
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Authors
Daniela Arias-Salvatierra, Ellen K. Silbergeld, Leonor C. Acosta-Saavedra, Emma S. Calderon-Aranda,