Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation

Article ID	Journal	Published Year	Pages	File Type
10815860	Cellular Signalling	2016	30 Pages	PDF

Keywords

PP2A mTORC1 MST1 PDK1 Jnk1 S6K1 FOX NMSC mitogen-activated protein kinase/ERK kinase IKK 4-hydroxytamoxifen 7-AAD ERK mTOR UVB 7-aminoactinomycin D MEF SCC PI3K PI3-kinase mTOR complex 2 Phosphoinositide-dependent protein kinase-1 Sirt1 ribosomal protein S6 kinase beta-1 IκB kinase extracellular-signal-regulated kinases Mdm2 mTOR complex 1 Akt/PKB Ultraviolet-B analysis of variance ANOVA forkhead box Apoptosis Non-melanoma skin cancer FoxO MEK Silent mating type information regulation 2 homolog 1 mouse double minute 2 homolog mouse embryonic fibroblasts mammalian target of rapamycin Mammalian target of rapamycin (mTOR)protein phosphatase 2A protein kinase B Cancer chemoprevention Squamous cell carcinoma Keratinocyte

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Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation

Authors

Robert P. Feehan, Lisa M. Shantz,