| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10815896 | Cellular Signalling | 2015 | 28 Pages |
Abstract
The present study reveals a flow-mediated adjustment of the apelin/APJ system in human EC in which APJ expression is induced by shear stress independently of its ligand. Furthermore, apelin-12 signaling is an essential regulatory element in endothelial NO synthesis.
Keywords
hCASMCAPJPECAM-1ERK 1/2VSMCN-nitro-l-arginine methyl esterGPCRESSeNOSHUVECPI3Kl-NAMEMAPKAktShear stressApelinVascular smooth muscle cellsEndothelial cellsendothelial nitric oxide synthaseplatelet endothelial cell adhesion molecule-1nitrite oxideNitric oxideprotein kinase Bmitogen-activated protein kinaseextracellular signal-regulated kinase 1/2G protein-coupled receptor
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Authors
Raila Busch, Anne Strohbach, Malte Pennewitz, Florian Lorenz, Martin Bahls, Mathias Christian Busch, Stephan Burkhard Felix,