Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10815903 | Cellular Signalling | 2015 | 13 Pages |
Abstract
The identification of this FRα-STAT3 signal transduction pathway activated by folic and folinic acid contributes to the understanding of the involvement of folic acid in preventing neural tube defects as well as in tumour growth. Previously, the role of folates in these diseases has been attributed to their roles as one-carbon unit donors following endocytosis into the cell. Our finding that folic acid can activate STAT3 via FRα adds complexity to the established roles of B9 vitamins in cancer and neural tube defects.
Keywords
ISGgp130GPiRFCSTAT3ERKFRαEGFJanus kinaseSTATFolic acidinterferonIFNinterferon stimulated geneepidermal growth factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Signal transducer and activator of transcriptionVitamin B9JAKReduced folate carrierextracellular signal-regulated kinaseglycophosphatidylinositolFolate receptorfolate receptor alpha
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Authors
Mariann F. Hansen, Eva Greibe, Signe Skovbjerg, Sarah Rohde, Anders C.M. Kristensen, Trine R. Jensen, Charlotte Stentoft, Karina H. Kjær, Camilla S. Kronborg, Pia M. Martensen,