| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816201 | Cellular Signalling | 2013 | 7 Pages |
Abstract
⺠Human adenosine A1 receptors heterodimerize with β1 and β2 adrenergic receptors. ⺠This causes alterations in receptor pharmacology, coupling, and downstream signaling. ⺠A1, β1, β2 heterodimerization creates novel and differential molecular interactions. ⺠Such cross-talk leads to physiological consequences and represent new drug targets.
Keywords
GPCRβ-Adrenergic receptor subtypesHEK-293A1ARcAMPG protein coupled receptorsG protein-coupled receptorsCyclic adenosine monophosphateImmunoblottingImmunofluorescenceImmunoprecipitationhuman embryonic kidney cellsHeterodimerizationPERKphosphorylated extracellular signal-regulated kinaseAdenosine receptorA1 adenosine receptorβ-adrenergic receptors
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Authors
P. Charukeshi Chandrasekera, Tina C. Wan, Elizabeth T. Gizewski, John A. Auchampach, Robert D. Lasley,