Article ID Journal Published Year Pages File Type
10816207 Cellular Signalling 2013 9 Pages PDF
Abstract
► We investigated the molecular mechanisms of celastrol-induced cancer apoptosis. ► We showed that celastrol induced the apoptosis of breast cancer MCF7 cells through AMPK. ► We found that p53/PLK-2 were involved in celastrol-induced MCF7 cells apoptosis. ► We understand the molecular mechanism of anti-tumor effects of celastrol on MCF-7 cells.
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Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Celastrol suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53-polo like kinase 2 (PLK-2) pathway
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