| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816208 | Cellular Signalling | 2013 | 8 Pages |
Abstract
⺠Distinct PLC and PLD signalling pathways of the psychotropic 5-HT2AR were measured. ⺠H452Y variant 5-HT2AR, associated with CNS disorders, and wild-type were compared. ⺠H452Y mutation selectively disrupts PLD signalling over conventional PLC signalling. ⺠H452Y mutation reduces direct binding of PLD1 to the 5-HT2AR carboxy-terminal tail. ⺠5-HT2AR residues 450-460 are implicated in PLD signalling and downstream responses.
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Authors
Zoe Barclay, Louise Dickson, Derek Robertson, Melanie Johnson, Pamela Holland, Roberta Rosie, Liting Sun, Helen Jerina, Eve Lutz, Sue Fleetwood-Walker, Rory Mitchell,