| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816209 | Cellular Signalling | 2013 | 28 Pages |
Abstract
⺠We examined WNT-3A-induced β-catenin and ERK1/2 signaling in primary microglia. ⺠WNT-3A signaling to β-catenin and ERK1/2 requires heterotrimeric G proteins. ⺠PTX blocks WNT-3A-induced LRP6 and DVL phosphorylation and β-catenin stabilization. ⺠WNT-3A regulates ERK1/2 via βγ, PLC, Ca2 + and MEK1/2-dependent mechanisms. ⺠WNT-3A-induced COX2 expression is regulated via the WNT/ERK1/2 pathway.
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Authors
Carina Halleskog, Gunnar Schulte,