Article ID Journal Published Year Pages File Type
10816216 Cellular Signalling 2013 12 Pages PDF
Abstract
► IL-6 signals independently of soluble IL-6 receptor in cardiomyocytes. ► IL-6 activates MAPK and PI-3-kinase in the absence of JAK/STAT activation. ► IL-6 induces hypertrophy and cytoprotection in the absence of JAK/STAT activation. ► IL-6 induced Erk-1 and 2 MAPK activation is necessary and sufficient for cytoprotection.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
p42/p44-MAPK and PI3K are sufficient for IL-6 family cytokines/gp130 to signal to hypertrophy and survival in cardiomyocytes in the absence of JAK/STAT activation
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