| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816219 | Cellular Signalling | 2013 | 8 Pages |
Abstract
⺠STAT3 cross-talks with Skp2/p27/p21 pathway in gastric cancer cells. ⺠IL-6/JAK2/STAT3 pathway participates in the progression of gastric cancers. ⺠STAT3 depletion downregulates Skp2 and thereby upregulates p27 and p21. ⺠STAT3 cross-talks with Skp2/p27/p21 to regulate cell motility, adherence and invasion. ⺠Caution needs to be taken for the effect of STAT3 inhibition on Skp2/p27/p21 pathway.
Keywords
ras homolog family member ApSTAT3JAK2MTSDAPISCFRhoAFAKGAPDHJanus Kinase 2FITCRECKIL-6Skp2MMPRhoA kinase4′,6-diamidino-2-phenylindoleE-cadE-cadherinstandard deviationinterleukin-6analysis of varianceANOVAEnzyme-linked immunosorbent assayELISAphosphorylated STAT3fluorescein isothiocyanatematrix metalloproteinaseMicrotubulesreversion-inducing-cysteine-rich protein with kazal motifsfocal adhesion kinaseglyceraldehyde-3-phosphate dehydrogenaseRock
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Zheng Wei, Xian Jiang, Haiquan Qiao, Bo Zhai, Lianfeng Zhang, Qiang Zhang, Yuanhong Wu, Hongchi Jiang, Xueying Sun,