| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816226 | Cellular Signalling | 2013 | 12 Pages |
Abstract
⺠We evaluate the intracellular Zinc concentrations and Zinc Transporter expression in RPMCs. ⺠We found that ZnT7 mRNA was strongly induced by HG. ⺠Overexpression of ZnT7 results in a decrease of apoptosis in the presence of HG. ⺠Knockdown of ZnT7 promotes the apoptosis of cells in the presence of HG. ⺠ZnT7 inhibits the apoptosis by activation of PI3K/Akt pathway.
Keywords
RIPAESRDN,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediaminehuman peritoneal mesothelial cellsZnTRadioimmune precipitation assayperitoneal dialysis fluidCAPDTGFDCF-DATPENTBSPI3KPBSDMEMFITCDulbecco's modified Eagle's mediumsiRNAAIFchronic kidney diseaseEnd-stage renal diseasetransforming growth factorTris-buffered salineZinc transporterApoptosisContinuous ambulatory peritoneal dialysisapoptosis-inducing factorphosphoinositide 3-kinasefluorescein isothiocyanatePhosphate-buffered salineCKDPropidium iodidePdfhigh glucose
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Authors
Xiuli Zhang, Dan Liang, Baolei Guo, Wenyan Deng, Zhi-Hong Chi, Yuan Cai, Lining Wang, Jianfei Ma,