| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816227 | Cellular Signalling | 2013 | 7 Pages |
Abstract
⺠Sphingosine kinases 1 and 2 (SK1 and SK2) are implicated in cancer. ⺠Inhibition of SK1, but not SK2, results in indirect antagonism of the Warburg effect. ⺠SK1 limits proteasomal degradation of c-Myc which might promote the Warburg effect. ⺠SK1 inhibitors might kill cancer cells by abrogation of the Warburg effect.
Keywords
Ap3APBSFHITSK1PARPNADPHGSHNACS1PERKLC3GSSGN-acetyl-cysteineROSWarburg effectSphingosine kinaseSphingosine kinase 1sphingosine 1-phosphateSDS-PAGESodium dodecyl sulfate polyacrylamide gel electrophoresisnot detectedOxidative stressDiadenosine triphosphateCancerextracellular signal regulated kinasePhosphate-buffered salineNicotinamide dinucleotide phosphateProteasomemicrotubule associated protein 1 light chain 3reduced glutathioneoxidized glutathioneGlycolysisReactive oxygen species
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Authors
David G. Watson, Francesca Tonelli, Manal Alossaimi, Leon Williamson, Edmond Chan, Irina Gorshkova, Evgeny Berdyshev, Robert Bittman, Nigel J. Pyne, Susan Pyne,