| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816276 | Cellular Signalling | 2007 | 17 Pages |
Abstract
⺠H2O2 driven ROS activates NF-κB and arrests normal HDF and A549 tumor cell cycling. ⺠HDFs prematurely senesce while A549 cells become apoptotic in response to ROS. ⺠Suppressing NF-κB activation exacerbates the ROS-mediated HDF senescence response. ⺠Inhibiting canonical NF-κB enhances ROS-induced A549 tumor cell apoptosis. ⺠The p53-p21Cip1/Waf1 axis drives the ROS-mediated senescence response of HDFs.
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Authors
Alexandros Sfikas, Christina Batsi, Evangelia Tselikou, George Vartholomatos, Nikolaos Monokrousos, Periklis Pappas, Savvas Christoforidis, Theodoros Tzavaras, Panagiotis Kanavaros, Vassilis G. Gorgoulis, Kenneth B. Marcu, Evangelos Kolettas,