Fullerene derivative prevents cellular transformation induced by JAK2 V617F mutant through inhibiting c-Jun N-terminal kinase pathway

Article ID	Journal	Published Year	Pages	File Type
10816277	Cellular Signalling	2012	11 Pages	PDF

Abstract

âº Fullerene derivative induced apoptosis of transformed cells by JAK2 mutant. âº Fullerene derivative inhibited JNK activation pathway. âº Fullerene derivative inhibited JAK2 mutant-induced tumorigenesis in nude mice.

Keywords

dichlorodihydrofluorescein Erythropoetin JAK2 V617F mutation ODC Ornithine decarboxylase MPNs CDK4 SOCS Apoptosis signal-regulating kinase 1 (ASK1)s.c.i.v.i.p.DCFH ERK EPO PBS Jnk FBS RT-PCR Janus kinase c-Jun N-terminal kinase c-Jun N-terminal kinase (JNK)DMSO ROS STAT TAE Apoptosis intraperitoneal Intravenous Dimethyl sulfoxide subcutaneous fetal bovine serum suppressor of cytokine signaling Fullerene signal transducers and activators of transcription Phosphate-buffered saline Myeloproliferative neoplasms reverse transcription–polymerase chain reaction mitogen-activated protein kinase JAK MAP kinase extracellular signal-regulated kinase cyclin-dependent kinase 4 Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

Fullerene derivative prevents cellular transformation induced by JAK2 V617F mutant through inhibiting c-Jun N-terminal kinase pathway

Authors

Megumi Funakoshi-Tago, Tatsuaki Nagata, Kenji Tago, Masaki Tsukada, Kazuyuki Tanaka, Shigeo Nakamura, Tadahiko Mashino, Tadashi Kasahara,