Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10816282 | Cellular Signalling | 2012 | 6 Pages |
Abstract
⺠PLCγ2 interacts with the Mg2 +-sensing channel-kinase TRPM7. ⺠The C2-domain of PLCγ2 is phosphorylated by TRPM7's Ser/Thr kinase. ⺠TRPM7-mediated PLCγ2 phosphorylation reveals two novel phospho-sites, T1045 and S1164. ⺠PLCγ2-S1164A mutation results in diminished BCR-mediated Ca2 +-signal under low Mg2 +.
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Authors
Francina Deason-Towne, Anne-Laure Perraud, Carsten Schmitz,