The impact of sleep deprivation on neuronal and glial signaling pathways important for memory and synaptic plasticity

Article ID	Journal	Published Year	Pages	File Type
10816309	Cellular Signalling	2012	10 Pages	PDF

Abstract

âº Hippocampal function is particularly sensitive to sleep loss. âº Sleep deprivation alters hippocampal glutamate, acetylcholine, and GABA systems. âº Sleep deprivation attenuates hippocampal cAMP signaling. âº Rescuing cAMP signaling prevents effects of sleep deprivation on the hippocampus. âº Astrocytes contribute to the effects of sleep deprivation on memory and plasticity.

Keywords

CREB cyclic AMP-dependent protein kinase A gamma-aminobutyric acid receptor N-ethylmaleimide-sensitive factor attachment protein receptor ERK PDE PDE4 mAChR nAChR NMDAR AMPAR pKa SNARE cAMP Astrocytes Sleep loss long-term potentiation LTP rapid eye movement sleep REM sleep Rolipram Transcription Phosphodiesterase Hippocampus cAMP response element binding protein extracellular signal-regulated kinase GABAR N-methyl-d-aspartate receptor nicotinic acetylcholine receptor Muscarinic cholinergic receptor Learning