| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816313 | Cellular Signalling | 2012 | 11 Pages |
Abstract
⺠Phospholipase Cε is a multifunctional enzyme that responds to inputs downstream of GPCRs and RTKs. ⺠Phospholipase Cε is a guanine nucleotide exchange factor for small GTPases such as Rap. ⺠Phospholipase Cε is a central participant in a novel cAMP-and Epac-dependent signaling module. ⺠Subcellular scaffolding of phospholipase Cε allows it to regulate specific functions. ⺠Phospholipase Cε regulates cardiac, pancreatic, and kidney functions as well as inflammation.
Keywords
ESCCET-1PLCRyRGLP-1PKC2-APBLPAEpacPDGFS1PT2DMGEFPKDGSISAKAPPIP2Neonatal rat ventricular myocyteNRVMinositol 1,4,5 triphosphateCaMKIIGPCRtPA12-O-tetradecanoylphorbol-13-acetatepKaIGF-1EGFIP3inositol phosphateSphingosine-1 phosphatelysophosphatidic acidinflammationCalcium-induced calcium releaseendothelin-1ISOisoproterenolDiabetesType 2 diabetes mellitusdiacylglycerolSarcoplasmic reticulumDAGepidermal growth factorCardiovascular functionguanine nucleotide exchange factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)platelet-derived growth factorinsulin-like growth factor 1Phosphatidylinositol 4,5 bisphosphatePhosphoinositide-specific phospholipase CAVMA kinase anchoring proteinExchange protein directly activated by cAMPprotein kinase Aprotein kinase DProtein kinase CSingle nucleotide polymorphismglucagon-like peptide-1SNPEsophageal squamous cell carcinomaCICRRyanodine receptorG protein-coupled receptor
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Authors
Alan V. Smrcka, Joan Heller Brown, George G. Holz,