| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816314 | Cellular Signalling | 2012 | 10 Pages |
Abstract
âºLPLI induces ERK activation and its translocation from cytoplasm to nucleus. âºActivated ERK upon LPLI interacts with Sp1 and activates it through phosphorylation. âºLPLI enhances transcriptional activity of Sp1 dependent on ERK. âºVEGF expression and proliferation are promoted by LPLI via activation of ERK/Sp1.
Keywords
EGFcyan fluorescence proteinGö6983LPLiHEK 293Thuman embryonic kidney 293TPD98059WCLMTAYFPPMSFCFPERKFACSSp1AngiogenesisFluorescence resonance energy transferFRETchromatin immunoprecipitationProliferationCo-IPepidermal growth factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)phenylmethylsulfonyl fluoridewhole cell lysateSpecificity protein 1Co-ImmunoprecipitationYellow Fluorescence ProteinCHiPextracellular signal-regulated kinase
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Authors
Jie Feng, Yingjie Zhang, Da Xing,