| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816317 | Cellular Signalling | 2012 | 9 Pages |
Abstract
⺠In foam cells TRIF-dependent TLR-4 signaling provoking IFNβ expression is blocked. ⺠Mono-ubiquitinated TANK inhibits TBK1 recruitment to TRAF3 and IRF3 activation. ⺠OxLDL stimulates TANK mono-ubiquitination by IRAK1/4 and Pellino3 activation. ⺠OxLDL-dependent foam cell desensitization is mediated by SR-A1.
Keywords
TBK1IKKεPPaseNAP1IFNβTNFaoxLDLTRAFIP-10IRF3nuclear factor kappa-light-chain-enhancer of activated B-cellsPBMCsLPSMYD88TBARSTLRMAPKNFκBTRIFarteriosclerosisinterferon βtumor necrosis factor aToll-like receptorMolecular biologyperipheral blood mononuclear cellsInterferon regulatory factor 3TNF receptor associated factorIRAKPhosphataseLeukocytesoxidized low density lipoproteinLipoproteinslipopolysaccharidetankthiobarbituric acid-reactive substancesSignal transductionmyeloid differentiation primary response gene 88Interferon-inducible protein-10mitogen activated protein kinasepoly(I:C)Polyinosinic–polycytidylic acidInterleukin-1 receptor-associated kinase
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Authors
Nico Tzieply, Anne-Marie Kuhn, Daniel Morbitzer, Dmitry Namgaladze, Annika Heeg, Liliana Schaefer, Andreas von Knethen, Liselotte E. Jensen, Bernhard Brüne,