Article ID Journal Published Year Pages File Type
10816325 Cellular Signalling 2012 9 Pages PDF
Abstract
► Blocking of the AT1R reduces pathological neovascularization in the mouse retina. ► Ang II modulates VEGF-induced angiogenesis through opposing effects of AT1R and AT2R. ► The pro-angiogenic effect of the AT1R requires activation of G12/13 proteins. ► The angiostatic effect of the AT2R involves Gi proteins, Src and Ser/Thr-kinases. ► The regulation of endothelial cells by VEGF and Ang II converges on RhoA activity.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Angiotensin II modulates VEGF-driven angiogenesis by opposing effects of type 1 and type 2 receptor stimulation in the microvascular endothelium
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