Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells

Article ID	Journal	Published Year	Pages	File Type
10816326	Cellular Signalling	2012	11 Pages	PDF

Abstract

âº SFKs selective inhibitors regulate migration and invasion in MDA-MB-231 cells. âº Dasatinib and PP2 inhibit cell proliferation at the G1 phase of the cell cycle. âº SU6656 blocks cytokinesis inducing polyploidy and multinucleation. âº SU6656 is a dual kinase inhibitor (SFKs and Aurora B kinase) in MDA-MB-231 cells. âº GSEA revealed that SU6656 significantly reduces the Src gene pathway.

Keywords

PDGF-R FGF-R Src family tyrosine kinases C-terminal Src kinase SU6656 e-r CSK VEGF-R MDA-MB-231 PP2 SFKs EGF-R IGF-1R PARP GSEA PRL-R DAPI 4',6-diamidino-2-phenylindole Aurora B kinase MTT BrdU bromodeoxyuridine Gene Set Enrichment Analysis Dasatinib Propidium iodide poly-ADP ribose polymerase Estrogen receptor platelet-derived growth factor receptor Insulin-like growth factor-1 receptor vascular endothelial growth factor receptor Epidermal growth factor receptor fibroblast growth factor receptor prolactin receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells

Authors

MarÃa Pilar Sánchez-Bailón, Annarica Calcabrini, Daniel Gómez-DomÃnguez, Beatriz Morte, Esther MartÃn-Forero, Gonzalo Gómez-López, Agnese Molinari, Kay-Uwe Wagner, Jorge MartÃn-Pérez,