| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816328 | Cellular Signalling | 2012 | 8 Pages |
Abstract
⺠Tg-evoked STIM1 tyrosine phosphorylation ocurred within the first 5 seconds of SOCE activation. ⺠STIM1 tyrosine phosphorylation mechanisms are both dependent and independent of changes in cytosolic calcium concentration. ⺠STIM1 tyrosine phosphorylation is required for STIM1/Orai1 interaction during SOCE activation. ⺠STIM1 is tyrosine phosphorylated by pp60src and Btk during SOCE in human platelets.
Keywords
STIM1Tris-buffered saline with 0.1% Tween 20SERCA2bTRPCSOCEPBSHBSThapsigarginTBSTDTTBSABtkHEPES-buffered saline[Ca2+]cbovine serum albuminBruton's tyrosine kinasedithiothreitolBosutinibendoplasmic reticulumcytosolic calcium concentrationTyrosine phosphorylationPhosphate-buffered salineStromal interaction molecule 1Human plateletsTransient receptor potential channelInositol trisphosphate receptor
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Authors
Esther Lopez, Isaac Jardin, Alejandro Berna-Erro, Nuria Bermejo, Ginés M. Salido, Stewart O. Sage, Juan A. Rosado, Pedro C. Redondo,