Dual specificity phosphatases 10 and 16 are positive regulators of EGF-stimulated ERK activity: Indirect regulation of ERK signals by JNK/p38 selective MAPK phosphatases

Article ID	Journal	Published Year	Pages	File Type
10816367	Cellular Signalling	2012	10 Pages	PDF

Abstract

âº DUSPs could influence acute EGF effects on ERK directly or indirectly. âº The DUSPs tested had no direct negative effects on ERK signalling. âº siRNAs targeting JNK/p38-specific DUSP 10 and DUSP 16 revealed indirect modulation. âº DUSPs 10 and 16 positively modulate EGF effects by reducing p38-mediated feedback. âº DUSPs are potential therapeutic targets with effects beyond preferred substrates.

Keywords

p38 c-Jun N-terminal kinase MAPK phosphatase dual specificity phosphatase epidermal growth factor mitogen-activated protein kinase

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

Preview

Dual specificity phosphatases 10 and 16 are positive regulators of EGF-stimulated ERK activity: Indirect regulation of ERK signals by JNK/p38 selective MAPK phosphatases

Authors

Ann R. Finch, Christopher J. Caunt, Rebecca M. Perrett, Krasimira Tsaneva-Atanasova, Craig A. McArdle,