| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816370 | Cellular Signalling | 2012 | 8 Pages |
Abstract
âºThe effects of BRCA1 variant Î14-15 on DNA repair was studied in MCF-7 cells. âºOverexpression of BRCA1Î14-15 decreases the DNA DSB repair capacity. âºBRCA1Î14-15 negatively influences IRIF kinetics and initial DSB repair phase. âºBRCA1Î14-15 expression impairs NHEJ activity. âºBRCA1Î14-15 expression does not change the sensitivity to mitomycin C.
Keywords
IRIFRPACDK2NLSb2mPARPPBMCsBRCTBRCA1 C-terminal domainCHK2CtIPNHEJGAPDHshRNASCDATRataxia telangiectasia and Rad3-relatedataxia telangiectasia mutatedaurora kinase ABRCA1/2RNA interferenceRNAishort-hairpin RNAVUSAURKADNA damageBeta-2-microglobulinreplication protein AAlternative splicingATMBreast cancerperipheral blood mononuclear cellscyclin-dependent kinase 2nuclear localization signalDNA double-strand breaknon-homologous end joiningVariants of uncertain significanceHomologous recombinationPost-irradiationpoly(ADP-ribose)polymeraseBRCA1glyceraldehyde-3-phosphate dehydrogenase
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Authors
Jan Sevcik, Martin Falk, Petra Kleiblova, Filip Lhota, Lenka Stefancikova, Marketa Janatova, Lenka Weiterova, Emilie Lukasova, Stanislav Kozubek, Petr Pohlreich, Zdenek Kleibl,