| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816377 | Cellular Signalling | 2012 | 10 Pages |
Abstract
⺠Akt negatively regulates the activation of NFAT through the B cell antigen receptor. ⺠Akt2, but not Akt1, inhibits antigen receptor-mediated activation of NFAT. ⺠Akt2 fails to block signaling upstream or downstream of calcium release from the ER. ⺠Akt2 inhibits sustained calcium release from the endoplasmic reticulum. ⺠Inhibition by is reversed by blocking Bcl-2 binding to the IP3 receptor.
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Authors
Victoria A. Martin, Wen-Horng Wang, Andrew M. Lipchik, Laurie L. Parker, Yantao He, Sheng Zhang, Zhong-Yin Zhang, Robert L. Geahlen,