ErbB380Â kDa, a nuclear variant of the ErbB3 receptor, binds to the Cyclin D1 promoter to activate cell proliferation but is negatively controlled by p14ARF

Article ID	Journal	Published Year	Pages	File Type
10816379	Cellular Signalling	2012	12 Pages	PDF

Abstract

âº We characterize here ErbB380kDa, a nuclear variant of the ErbB3 receptor. âº This variant is devoid of the extracellular domain of the receptor. âº Nuclear ErbB380kDa binds the Cyclin D1 promoter and up-regulates proliferation. âº The tumor suppressor p14ARF negatively regulates this nuclear pathway. âº Nuclear ErbB3 could counteract cancer therapies targeting the EGF-R cytoplasmic pathways.

Keywords

p14ARF CyclinD1 Proliferation

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

Preview

ErbB380Â kDa, a nuclear variant of the ErbB3 receptor, binds to the Cyclin D1 promoter to activate cell proliferation but is negatively controlled by p14ARF

Authors

Laëtitia Andrique, Dominique Fauvin, Mahmoud El Maassarani, HélÃ¨ne Colasson, Brigitte Vannier, Paule Séité,