Glucocorticoids reduce inflammation in cystic fibrosis bronchial epithelial cells

Article ID	Journal	Published Year	Pages	File Type
10816382	Cellular Signalling	2012	7 Pages	PDF

Abstract

âº We examine two pathways implicated in IL-8 secretion from bronchial cells. âº Glucocorticoids reduce inflammation in cystic fibrosis lung cells. âº p38 MAPK controls IL-8 release and also glucocorticoid receptor activation. âº A synergistic effect of glucocorticoid and p38 inhibitor is observed on IL-8 release.

Keywords

ERK p-p38 CXCR MUC5AC CFTR AP-1 LUC PVDF Jnk AMPK NF-κB AICAR DEX AMP-activated protein kinase c-Jun N-terminal kinase MAPK p38 MAPK siRNA small interfering ribonucleic acid inflammation interleukin Chronic obstructive pulmonary disease COPD TAT Tyrosine aminotransferase Dexamethasone cystic fibrosis transmembrane conductance regulator Lung TNF-α nuclear factor-κB Phospho-p38 Cystic fibrosis luciferase activator protein-1 mitogen-activated protein kinase Polyvinylidene fluoride extracellular signal-regulated kinase Glucocorticoids glucocorticoid receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Glucocorticoids reduce inflammation in cystic fibrosis bronchial epithelial cells

Authors

Carine Rebeyrol, Vinciane Saint-Criq, Loïc Guillot, Laure Riffault, Harriet Corvol, Katarina Chadelat, David W. Ray, Annick Clement, Olivier Tabary, Philippe Le Rouzic,