| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816467 | Cellular Signalling | 2012 | 9 Pages |
Abstract
⺠In the present study, we identify PDCD6 as a key regulator of tumor growth and angiogenesis. ⺠The increase in endothelial PDCD6 is a direct result of VEGF stimulation and suppress phosphorylation of signaling regulators downstream from PI3K, including Akt, mTOR, and GSK-3β. ⺠These data provide an important conceptual advance in our understanding of the modulation of cellular angiogenesis in ovarian tumor and support the potential for targeting PI3K/Akt as a therapeutic approach.
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Authors
Seung Bae Rho, Yong Jung Song, Myong Cheol Lim, Seung-Hoon Lee, Boh-Ram Kim, Sang-Yoon Park,