| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816491 | Cellular Signalling | 2012 | 6 Pages |
Abstract
⺠We present a model in which Cul7-Rbx1 can promote ubiquitination of Cul1 substrates by forming high order complexes with Cul1-Rbx1. ⺠Binding of Cul1-Rbx1 to Cul7-Rbx1 is mediated via heterodimerization of Fbxw8 with other F-box proteins. ⺠The formation of this high order complex is likely to increase polyubiquitination efficiency. ⺠Cul7 can be modified by Nedd8 via Nedd8 E2 conjugating enzyme Ubc12 in vitro.
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Authors
Wanpen Ponyeam, Thilo Hagen,