| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816495 | Cellular Signalling | 2012 | 7 Pages |
Abstract
⺠The mTORC2 kinase component Protor-2 is found to interact with the mRNA destabilizing factor tristetraprolin. ⺠Modulation of Protor-2 levels specifically alters the stability of mRNAs known to be degraded by tristetraprolin. ⺠Inhibition of Protor-2 expression blocks the association of tristetraprolin with stress granules or processing bodies during stress. ⺠We conclude that Protor-2 regulates tristetraprolin mediated mRNA turnover and may link mTORC2 signaling to regulated mRNA stability.
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Authors
Brent Holmes, Nicholas Artinian, Lauren Anderson, Jheralyn Martin, Janine Masri, Cheri Cloninger, Andrew Bernath, Tariq Bashir, Angelica Benavides-Serrato, Joseph Gera,