| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816497 | Cellular Signalling | 2012 | 9 Pages |
Abstract
⺠FOXF1 knockdown renders p53-null and p21-null cells susceptible to DNA rereplication. ⺠FOXF1 knockdown activates the ATM/ATR-p53-p21 DNA damage checkpoint pathways. ⺠Activation of the p53-p21 pathway by FOXF1 knockdown inhibits the CDK2-Rb cascade. ⺠Inhibition of CDK2 by elevated p21 induces G1 arrest to prevent DNA rereplication. ⺠FOXF1 is silenced in breast and colorectal cancer cell lines with inactive p53.
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Authors
Pang-Kuo Lo, Ji Shin Lee, Saraswati Sukumar,