Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10816499 | Cellular Signalling | 2012 | 8 Pages |
Abstract
⺠Absence of aminoacids induces hepatocyte apoptosis, however some cells escape from cell death. ⺠Survival cells show higher capacity to proliferate and resist to apoptotic stimuli. ⺠AKT, mTOR, ERKs and the EGFR pathways are activated in these cells. ⺠Furthermore, they show adaptation to counteract the oxidative stress.
Keywords
EGFRTGF-βγ-GCS2′,7′-dichlorodihydro-fluorescein diacetatemTORFBSH2DCFDAHCCPTKsROSAminoacidsHepatocyte proliferationtransforming growth factor-betaApoptosislow protein dietLiver carcinogenesisfetal bovine serummammalian target of rapamycinHepatocellular carcinomacomplete mediumReactive oxygen species (ROS)Reactive oxygen speciesEpidermal growth factor receptor
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Authors
Andrea N. Chisari, Patricia Sancho, Laia Caja, Esther Bertran, Isabel Fabregat,