| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816500 | Cellular Signalling | 2012 | 9 Pages |
Abstract
⺠OTR and β2AR both modulate ERK1/2 signalling in myometrial cells. ⺠β2AR is biased by OTR toward Gi/PI3 kinase/PKCz/src to activate ERK1/2. ⺠Co-expression of OTR/β2AR in HEK 293 cells recapitulates data in myometrial cells. ⺠The simplest explanation for this is an OTR/β2AR heterodimer (see companion article).
Keywords
EGFβ2ARDMEMFBSGPCRCyPHRPERKCFPEGFRcAMPDMSODNADulbecco's modified Eagle's mediumCyclic adenosine monophosphateadenylyl cyclasedeoxyribonucleic aciddimethylsulphoxidecyanopindololfetal bovine serumEpithelial growth factorHorseradish peroxideextracellular signal-regulated kinaseβ2-adrenergic receptorEpithelial growth factor receptorG protein-coupled receptor
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Authors
Paulina K. Wrzal, Eugénie Goupil, Stéphane A. Laporte, Terence E. Hébert, Hans H. Zingg,