| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816580 | Cellular Signalling | 2013 | 8 Pages |
Abstract
⺠CLA stimulates apoptosis by activation of the GPCR/PLC/IP3/CaMKK/AMPK pathway. ⺠CLA stimulation of oxidative stress plays a role in mediating the apoptotic effect. ⺠p38 MAPK is the effector mediating apoptotic signals from AMPK and oxidative stress.
Keywords
DPPPIP3RPARPPLCGQIGαqGPCRCaMKKIP3N-acetyl-l-cysteinepKahptAMP kinaseCLA2-aminoethyl diphenylborinateNACPI-PLCSDHPC-PLCSRB1,4,5-inositol trisphosphatec9,t11-CLAAMPKAMP-activated protein kinaseG protein coupled receptorMAPKROSER stressconjugated linoleic acidPolyunsaturated fatty acidPUFABAPTA-AMOxidative stressdiphenyl-1-pyrenylphosphinesulforhodamine Bsuccinate dehydrogenaseendoplasmic reticulumphospholipase CHypotaurineprotein kinase Amitogen-activated protein kinasepoly ADP ribose polymeraseReactive oxygen speciesIP3 receptor
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Authors
Yung-Chung Hsu, Margot M. Ip,