| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816584 | Cellular Signalling | 2011 | 12 Pages |
Abstract
âºThe Migr1-PPAR retroviral system allows for efficient sorting of cell over-expressing PPARs. âºHaCaT cells over-expressing PPARs exhibit enhanced ligand-induced gene expression. âºNo change in PPARβ/δ target gene expression by retinoic acid occurs in HaCaT cells over-expressing PPARβ/δ. âºOver-expression of PPARβ/δ does not interfere with PPARγ ligand induced target gene expression. âºOver-expression of PPARβ/δ inhibits pro-inflammatory cytokine expression and secretion.
Keywords
UVBADRPPARPIL8Retinoid X receptorIL6cytochrome P450 26a1cyp26a1CRABP-IIPPARPPARγANGPTL4GAPDHIRESeGFPNSAIDRARRXRqPCRFABP5FBSDMEMTNFαPDPK1atRADMSOPPARβ/δall-trans retinoic acidinflammationinterleukin 6Interleukin 8ELISAEnzyme-linked immunosorbent assaytumor necrosis factor αDulbecco's minimal essential mediumApoptosisDimethylsulfoxideRetinoic acidinternal ribosome entry sitefetal bovine serumNon-steroidal anti-inflammatory drugquantitative real-time polymerase chain reactionenhanced green fluorescent proteinangiopoietin-like protein 4Adipocyte differentiation-related proteinpoly (ADP-ribose) polymeraseHuman keratinocytesglyceraldehyde 3-phosphate dehydrogenaseRetinoic acid receptorperoxisome proliferator-activated receptor
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Authors
Michael G. Borland, Combiz Khozoie, Prajakta P. Albrecht, Bokai Zhu, Christina Lee, Tejas S. Lahoti, Frank J. Gonzalez, Jeffrey M. Peters,