| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816587 | Cellular Signalling | 2011 | 9 Pages |
Abstract
⺠Rap1 activity is regulated by both PDZ-GEF and Epac1 to control endothelial barrier. ⺠Epac1 and Rap1 enhance barrier function by inducing junctional actin. ⺠PDZ-GEF and Rap1 are required for basal endothelial barrier function. ⺠PDZ-GEF and Rap1 reduce endothelial junction motility.
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Authors
Willem-Jan Pannekoek, Jantine J.G. van Dijk, On Ying A. Chan, Stephan Huveneers, Jelena R. Linnemann, Emma Spanjaard, Patricia M. Brouwer, Anne Jan van der Meer, Fried J.T. Zwartkruis, Holger Rehmann, Johan de Rooij, Johannes L. Bos,