| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10816590 | Cellular Signalling | 2011 | 10 Pages |
Abstract
⺠WP1130 is a more potent inhibitor of Jak2 signaling than its parent compound AG490. ⺠WP1130 induces formation of K63-linked ubiquitin polymers on Jak2. ⺠Jak2 ubiquitination by WP1130 results in its trafficking to perinuclear aggresomes. ⺠WP1130 inhibits a deubiquitinase (DUB) specific for Jak2 ubiquitin.
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Authors
Vaibhav Kapuria, Alexander Levitzki, William G. Bornmann, David Maxwell, Waldemar Priebe, Roderick J. Sorenson, Hollis D. Showalter, Moshe Talpaz, Nicholas J. Donato,