| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10817120 | Cellular Signalling | 2005 | 10 Pages |
Abstract
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that is known to mediate diverse cellular responses including cell growth, survival, and migration. Most of these effects have been attributed to its binding to a specific subfamily of G protein-coupled receptors (GPCR), namely S1P1-5. Recent studies have suggested that S1P also plays a prominent role in the contraction of various types of smooth muscle. This review provides a brief overview of its role in this process and also highlights how S1P-dependent signaling serves as an important regulator of smooth muscle contraction.
Keywords
ERKCNPPLCPKCPTXS1PGPCRPKGpKaASMS1PReNOSMLCMYPT1JnkPLDMyosin phosphatase targeting subunit 1ZIPKMEFFTY720-PHASMSphKHDLMLCKMLCPc-Jun N-terminal kinasehigh-density lipoprotein[Ca2+]iContractionSphingosine kinaseSphingosine-1-phosphateSphinganine-1-phosphateILKChoChinese Hamster OvarydiacylglycerolSarcoplasmic reticulumRhoDAGRho kinasemyosin light chainmyosin light chain kinaseROKpertussis toxinendothelial nitric oxide synthaseendoplasmic reticulumsmooth muscle Human airway smooth muscleAirway smooth muscleintracellular calcium concentrationMyosin light chain phosphatasephospholipase CPhospholipase DLow-density lipoproteinLDLmouse embryonic fibroblastNitric oxideprotein kinase Aprotein kinase GProtein kinase CC-type natriuretic peptideCalciumextracellular signal-regulated kinaseintegrin-linked kinaseS1P receptorG protein-coupled receptor
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Kenneth R. Watterson, Paul H. Ratz, Sarah Spiegel,