Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10817232 | Clinica Chimica Acta | 2015 | 7 Pages |
Abstract
In the United States of America male prostate cancer (PCa) is the most dominant malignancy and the second highest cause of cancer-related mortality risk compared to lung and colon cancers. MicroRNAs (miRNAs) are a class of endogenously expressed small, non-coding, single-stranded RNA which function as regulators of gene expression. They influence various physiological and pathophysiological processes. In this review, we focus on the regulation of miRNAs in prostate cancer and their mechanisms which contribute to prostate carcinogenesis. The relation of miRNAs with androgen signaling is highlighted and the prospects of miRNAs for clinical therapies are discussed.
Keywords
ZEB2E2 transcription factorRho-associated, coiled-coil containing protein kinase 1Slit3E2F2LAMC1E2FELK1SENP1Zinc finger E-box binding homeobox 2CDK4CRPCSlit2DGCR8B-cell translocation gene 2MicroRNA (miRNA)Bcl2CXCR4IGF1RSox9HIF-1αERKCdk6AndrogenMesenchymal-to-Epithelial TransitionEMTRaf1Prostate cancerCastration-resistant prostate cancercyclin-dependent kinase 6Phosphatidylinositol 3-kinaseB-cell lymphoma 2METC-X-C chemokine receptor type 4post-transcriptionPtenextracellular signal-regulated kinasescyclin-dependent kinase 4epithelial-to-mesenchymal transitioninsulin-like growth factor 1 receptor
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Authors
Kasomva Khanmi, Savarimuthu Ignacimuthu, Michael Gabriel Paulraj,