Association of genetic polymorphisms of RANK, RANKL and OPG with bone mineral density in Chinese peri- and postmenopausal women

Article ID	Journal	Published Year	Pages	File Type
10817947	Clinical Biochemistry	2013	9 Pages	PDF

Abstract

Our findings suggest that OPG and RANK but not RANKL genetic polymorphisms influence BMD mainly in the femoral neck in peri- and postmenopausal Chinese women. This contributes to the understanding of the role of genetic variation in this pathway in determining bone health.

Keywords

RANKL YSM NF-κB OPG DXA GLM SSCP MALDI-TOF BMD Osteoprotegerin standard deviation ANOVA one-way analysis of variance Bone mineral density dual energy X-ray absorptiometry Rank World Health Organization Years since menopause body mass index BMI Coefficient of Variation Nuclear factor-kappa B matrix assisted laser desorption ionization-time of flight Generalized linear model Genome-wide association study GWAS polymerase chain reaction PCR Polymorphism Single nucleotide polymorphism Osteoporosis SNP WHO