A cause of falsely low HDL concentrations in HIV-infected patients: increased polyclonal serum immunoglobulin

Although interference by any HIV therapy drug cannot be completely ruled out, our results showed that when high immunoglobulin concentrations existed in the patient's serum, the direct HDL-c method yielded low or undetectable HDL-c values. The high initial absorbance observed suggested an interaction between immunoglobulins and the first reagent of the method, producing a complex that scattered light and falsely decreased HDL-c concentrations.