| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10818299 | Clinical Biochemistry | 2005 | 13 Pages |
Abstract
Non-enzymatic glycation products are a complex and heterogeneous group of compounds which accumulate in plasma and tissues in diabetes and renal failure. There is emerging evidence that these compounds may play a role in the pathogenesis of chronic complications associated with diabetes and renal failure. So measurement of the products of non-enzymatic glycation has a twofold meaning: on one hand, measurement of early glycation products can estimate the extent of exposure to glucose and the subject's previous metabolic control; on the other hand, measurement of intermediate and late products of the glycation reaction is a precious instrument in verifying the relationship between glycation products and tissue modifications. This review summarizes current knowledge about the diagnostic utility of measuring non-enzymatic glycation products.
Keywords
DCCTCAPDIFCCPDGFRIARAGECMLNBTAdvanced glycation end-products (AGE)EDICIgGMatrix-assisted laser desorption mass spectrometryRCOEGFimmunoglobulin type GVCAMNF-κBGC/MSIgf1LC/ESI/MSRadio immunoassayenzyme linked immunosorbent assayAmerican Diabetes AssociationEpidemiology of Diabetes Interventions and ComplicationsDiabetesnitro blue tetrazoliumELISAtumor necrosis factor αContinuous ambulatory peritoneal dialysisAgeChronic complicationsEndothelial growth factorplatelet derived growth factorinsulin-like growth factor 1TNF-αnuclear factor κBInternational Federation of Clinical Chemistrylow density lipoproteinLDLAmadori productadvanced glycation end-productsvascular cell adhesion moleculeRenal failureHemodialysisADACarboxymethyl lysinehigh performance liquid chromatographyHPLCgas chromatography/mass spectrometryDiabetes Control and Complications Trialreceptor for AGE
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Authors
Annunziata Lapolla, Pietro Traldi, Domenico Fedele,