| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10822524 | Current Opinion in Structural Biology | 2012 | 5 Pages |
Abstract
⺠Golgi mannosidase II (GMII) is a core component of the N-glycosylation pathway. ⺠GMII inhibitors are of interest as potential anti-cancer or anti-infection compounds. ⺠Structural analysis of the Drosophila GMII (dGMII) has shed light on the catalytic process and mode of inhibition. ⺠The mechanism by which GMII binds the substrate and then rearranges to cleave two different glycosidic linkages is described. ⺠Novel GMII inhibitors show effectiveness in inhibiting the growth of tumor cells.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
David R Rose,