| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10822533 | Current Opinion in Structural Biology | 2012 | 9 Pages |
Abstract
⺠Multiple structural methodologies must be combined to fully describe the macromolecular rearrangements that underlie function. ⺠Interpretation of cryo-EM studies is greatly aided by labeling and biochemical data when atomic structures are lacking. ⺠Time-resolved methods like SAXS can identify structural transitions in a conformational pathway, for more detailed study. ⺠Elucidation of dynamic pathways is aided by molecular dynamics while constraining movements to the cryoEM envelope.
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Authors
Gabriel C Lander, Helen R Saibil, Eva Nogales,